@article{APS6923,
author = {Yi Zhang and Shuang-Zhen Gu and Yong-Chang Hao and Li-Lin Song and Shu-Mei Guo and Shen-Gui Lu},
title = {Effects of sodium pentobarbital on electric and mechanical activities of guinea pig papillary muscle},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of sodium pentobarbital (SP) on the action potential (AP) and contraction of guinea pig papillary muscle.
METHODS: Using conventional glass microelectrode and mechanical recording of myocardium contraction.
RESULTS: SP (> or = 10 mumol.L-1) prolonged the AP duration (APD) and effective refractory period (ERP), while amplitude (APA) and Vmax of phase 0 showed no changes. The effects of SP were abolished by pretreatment with cromakalim, an agonist of ATP-sensitive K+ channel. The maximal isometric tension (Pmax) and velocity of tension development (dT/dt) were decreased to 51% and 48% of control, respectively. The first postrest beat (B1) and second postrest beat (B2) were also depressed.
CONCLUSION: SP affected the action potential by reducing activities of the K+ channels and reduced the contraction of guinea pig myocardium.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6923}
}