@article{APS6911,
author = {Wei-Li Bao and Shi-Duo Chen and Jie-Shi Cheng and An-Zhong Zhang},
title = {Inhibitory effects of dextromethorphan on c-fos protein expression during focal cerebral ischemia in rats},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {5},
year = {2016},
keywords = {},
abstract = {AIM: To study the effect of dextromethorphan (DM) in focal cerebral ischemia.
METHODS: The c-fos protein was detected immunohistochemically in the brain of rats after focal cerebral ischemia (induced by placing a nylon thread in the lumen of the internal carotid artery) with and without treatment with DM.
RESULTS: Focal cerebral ischemia induced c-fos protein expression outside the core territory of the middle cerebral artery (MCA) and neuronal damage in the core territory of the MCA. There was an evident expression of c-fos protein in the ipsilateral regions outside the MCA territory (e.g. cingulate cortices, piriform cortices and entorhinal cortices), and in the contralateral regions of hippocampus after 4-h reperfusion following 1-h MCA occlusion. But morphological results showed severe edema and neuronal damage in the core territory and the ipsilateral hippocampus. DM blocked both the c-fos protein induction and neuronal damage in all regions.
CONCLUSION: DM reduced c-fos protein expression and blocked the neuronal damage after focal cerebral ischemia.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6911}
}