@article{APS6889,
author = {Chun-Lai You and Zhao-Feng Han and Yu-Shu Qu and Yi-Ming Wang},
title = {Antagonism of l-stepholidine against bromocriptine-inhibition on prolactin level in lactational rats},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the antagonism of l-stepholidine (SPD) against bromocriptine (Bro)-inhibition on prolactin (PRL) level.
METHODS: Bro (0.5 mg.kg-1.d-1, s.c.) reduced the PRL and caused a dysplasia of mammary gland in lactational rats. The weight growing of newborn rats was retarded. The PRL of the lactational rats was assessed by immunoradiometric assay (IRMA); the weight of newborn rats and development of mammary glands in lactational rats were also examined. Antagonism of SPD was evaluated.
RESULTS: SPD (30 & 100 mg.kg-1.d-1, i.p.) obviously antagonized the Bro that induced lowering the PRL level in lactational rats, the PRL was 11 +/- 4 & 23 +/- 6 micrograms.L-1 (NS 7 +/- 2) respectively on d 15 of postpartum and the development of mammary gland in lactational rats was normal. The newborn rats grew rapidly in 11-15 d.
CONCLUSION: SPD possessed an antagonism with Bro inhibition on D2 receptors located in the pituitary gland, and was an antagonist of dopamine D2 receptors.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6889}
}