@article{APS6888,
author = {Jian-Xin Zeng and Hong-Yu Cao and Qing Li and Zhi Xu and Zhi-Bin Guo},
title = {Effects of oxymatrine on arrhythmia in dogs with myocardial infarction},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {4},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of oxymatrine (Oxy) on arrhythmia in dogs with myocardial infarction.
METHODS: Partly ligating the left anterior descending coronary artery in the open-chest dogs produced myocardial infarction of left anterior ventricular wall. After 5-8 d, the diastolic excitability threshold (DET), the effective refractory periods (ERP) and arrhythmias were determined by programmed electric stimulation (PES).
RESULTS: Oxy (i.v. 50 mg.kg-1) increased DET from 2.53 +/- 1.28 to 3.19 +/- 1.62 V, lengthened ERP from 182 +/- 25 to 219 +/- 43 ms at normal region and from 206 +/- 49 to 235 +/- 55 ms at infarct region in left ventricle, but had no effects on dispersion of ERP, QTc interval and ventricular tachycardia (VT) or ventricular fibrillation (VF). Procainamide (Pro) (i.v. 25 mg.kg-1) increased DET and lengthened ERP and QTc interval, but decreased the dispersion of ERP. Pro prevented PES-induced VT/VF and spontaneous ischemia-related VF.
CONCLUSION: The increased DET and lengthened ERP of Oxy are its anti-arrhythmic mechanism.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6888}
}