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LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression

   
@article{APS6762,
	author = {Dong-dong Wu and Li Huang and Lei Zhang and Le-yu Wu and Yuan-chao Li and Linyin Feng},
	title = {LLDT-67 attenuates MPTP-induced neurotoxicity in mice by up-regulating NGF expression},
	journal = {Acta Pharmacologica Sinica},
	volume = {33},
	number = {9},
	year = {2016},
	keywords = {},
	abstract = {Aim: To investigate the neuroprotective effects of LLDT-67, a novel derivative of triptolide, in MPTP-induced mouse Parkinson's disease (PD) models and in primary cultured astrocytes, and to elucidate the mechanisms of the action.
Methods: In order to induce PD, C57BL/6 mice were injected MPTP (30 mg/kg, ip) daily from d 2 to d 6. MPTP-induced behavioral changes in the mice were examined using pole test, swimming test and open field test. The mice were administered LLDT-67 (1, 2, or 4 mg/kg, },
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6762}
}