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Effects of Panax notoginseng saponins on monophasic action potentials of heart and automaticity and contractility of isolated atria

   
@article{APS6749,
	author = {Jie-Qiu Chen and Yue-Guang Zhang and Chuan Xiong and Shao-Zhen Zhang and Qing Zeng and Ming-Zhi Rong},
	title = {Effects of Panax notoginseng saponins on monophasic action potentials of heart and automaticity and contractility of isolated atria},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {The effects of Panax notoginseng saponins (PNS) on monophasic action potentials (MAP) recorded from the myocardial surface by means of contact electrode were studied in 30 open-chest rabbits. The MAPA was increased and MAPD50, MAPD90 were prolonged with PNS (100, 200 mg.kg-1, iv), while the Vmax remained unchanged. PNS (300-1200 micrograms.ml-1) inhibited the automaticity of isolated guinea pig right atria and the contractility of the left atria. The positive inotropic action of ouabain (0.2 mumol.L-1) on isolated guinea pig left atria was decreased in the presence of PNS 300 micrograms.ml-1.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6749}
}