@article{APS6733,
author = {Ping Li and Hong-zhen Yu and Xin-xin Zhang and Li Gan and Chun-liu Zhu and Yong Gan},
title = {Absorption enhancement of adefovir dipivoxil by incorporating MCT and ethyl oleate complex oil phase in emulsion},
journal = {Acta Pharmacologica Sinica},
volume = {31},
number = {7},
year = {2016},
keywords = {},
abstract = {Aim: To improve the oral absorption of adefovir dipivoxil (ADV) by employing MCT and the esterase inhibitor ethyl oleate (EO) as a complex oil phase in emulsion.
Methods: EO was used as the esterase inhibitor, and its inhibitory effect on esterase activity was assessed in rat intestinal homogenates. ADV emulsions with or without EO were prepared. The emulsions' protective effect against intestinal metabolism was evaluated in rat luminal contents, ex vivo, as well as in vivo.
Results: The IC50 of EO in intestinal mucosal homogenates was 2.2 mg/mL. The emulsions exhibited significant protective effects in rat luminal contents compared to a simple suspension (98.7%, 96.3%, 95.7% vs. 74.7%, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6733}
}