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Initial experience of heroin use under a two-chained operant schedule influences drug-seeking behavior after one month of abstinence

   
@article{APS6667,
	author = {Bin Lu and Mu Li and Yuan-yuan Hou and Jie Chen and Zhi-qiang Chi and Jing-gen Liu},
	title = {Initial experience of heroin use under a two-chained operant schedule influences drug-seeking behavior after one month of abstinence},
	journal = {Acta Pharmacologica Sinica},
	volume = {31},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Aim: To evaluate the influence of an initial heroin experience under a modified two-chained training schedule on drug-seeking behavior after a long abstinence period.
Methods: Rats were trained to respond for intravenous heroin (120 μg/kg) under a heterogeneous chained schedule of reinforcement using different responses in the first and second links of the chain. Animals received low-frequency drug administration training for four days and were then subjected to one month of abstinence in their home cages. Heroin-seeking behavior induced by re-exposure to the first chain associated context or discriminative stimuli was assessed after abstinence.
Results: Almost all animals could acquire operant skills quickly under the two-chained schedule training for four days, as measured in first active response latency, travel speed and goal-box enter latency. Both first chain associated context and discriminative stimulus could reinstate heroin-seeking behavior after one month abstinence.
Conclusion: These observations suggest that an early experience of drug use is sufficient to maintain heroin-seeking behavior even after a one month abstinence.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6667}
}