@article{APS6646,
author = {Wen Shang and Ping Han and Cheng-bing Yang and Xiao-wen Gu and Wei Zhang and Li-ping Xu and Shou-ting Fu and Ding-feng Su and He-hui Xie},
title = {Synergism of irbesartan and amlodipine on hemodynamic amelioration and organ protection in spontaneously hypertensive rats},
journal = {Acta Pharmacologica Sinica},
volume = {32},
number = {9},
year = {2016},
keywords = {},
abstract = {Aim: To investigate the synergism of low-doses of amlodipine and irbesartan on reduction of blood pressure variability (BPV), amelioration of baroreflex sensitivity (BRS) and organ protection in spontaneously hypertensive rats (SHR).
Methods: The rats were administered amlodipine (1 mg·kg−1·d−1) alone, irbesartan (10 mg·kg−1·d−1) alone, or the combination of the two drugs for 4 months. The drugs were mixed into the rat chow. Blood pressure (BP) was continuously monitored in conscious animals. After the determination of BRS, the rats were killed for morphological evaluation of organ damages.
Results: The combination of low-dose irbesartan and amlodipine had statistically significant synergism on reduction of BP and BPV, amelioration of BRS and organ protection in SHR. Multiple regression analysis showed that the decrease in left ventricular hypertrophy was associated with the decrease in systolic BPV (r=0.665, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6646}
}