@article{APS6641,
author = {Wei Lu},
title = {Blocking NMDA receptor at rest: a possible alleviation of depression},
journal = {Acta Pharmacologica Sinica},
volume = {32},
number = {9},
year = {2016},
keywords = {},
abstract = {D epression is a common but serious illness, which is described as a state of low mood or mood disorder that involves feelings of sadness lasting for two weeks or longer[1]. Depressed people may suffer from a spectrum of syndromes, including change of sleep habitation or pattern, dramatic weight loss, cognitive impairments or even suicide. One conventional antidepressant medication is selective serotonin re-uptake inhibitor[2, 3]. However, the weeks delay of its efficacy constitutes the major drawback of this treatment[3]. Therefore, fast-acting antidepressants are urgently needed for clinical treatment of depression. Autry et al. reported in a recent issue of Nature that N-methyl-D-aspartate receptor (NMDAR) antagonists could be such candidates by triggering rapid behavioural antidepressant responses[4].},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6641}
}