@article{APS6622,
author = {Jiao Qian and Ai-jun Liu and Wei Zhang and Zhi-peng Wen and Li-li Lin and Jing-hang Wang and Ding-feng Su and Jian-guo Liu},
title = {Protective effects of betaglucin on myocardial tissue during myocardial infarction in rats and dogs},
journal = {Acta Pharmacologica Sinica},
volume = {30},
number = {8},
year = {2016},
keywords = {},
abstract = {Aim: To test the protective effects of betaglucin, a novel beta-glucan, on models of myocardial infarction (MI) in rats and dogs.
Methods: The left anterior descending (LAD) coronary artery occlusion model was used to induce an MI in rats and dogs. Three doses of betaglucin (10, 30 and 100 mg/kg), propranolol (positive control, 1 mg/kg) and vehicle alone (5% glucose solution) were administered before LAD occlusion, and characteristics of the resulting MI were subsequently assessed. In anesthetized dogs, blood pressure, heart rate, ventricular function, coronary artery blood flow and myocardial oxygen consumption were determined before and after the drug administration.
Results: The MI mass in both rats and dogs was significantly reduced by betaglucin (30 and 100 mg/kg, P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6622}
}