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Adenovirus-mediated delivery of p27KIP1 to prevent wound healing after experimental glaucoma filtration surgery

  
@article{APS6610,
	author = {Jian-gang Yang and Nai-xue Sun and Li-jun Cui and Xiao-hua Wang and Zhao-hui Feng},
	title = {Adenovirus-mediated delivery of p27KIP1 to prevent wound healing after experimental glaucoma filtration surgery},
	journal = {Acta Pharmacologica Sinica},
	volume = {30},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Aim:  The aim of the study was to evaluate the outcome of adenovirus-mediated p27KIP1 (Ad-p27) expression on wound healing after filtration surgery and to investigate the inhibition of cell proliferation induced by Ad-p27.
Methods:  We constructed the adenovirus recombinant vector Ad-p27 and administered it to a rabbit model of glaucoma filtration surgery by subconjunctival injection; phosphate-buffered saline (PBS) and mitomycin C (MMC) were used as controls. Intraocular pressure (IOP), bleb scores, and anterior chamber depths were observed during a 28-d period. Histological examinations, fluorescence observations and Western blot analyses were evaluated.
Results:  Ad-p27 enhanced the surgical outcome and inhibited cell proliferation when compared with PBS. Bleb scores in the Ad-p27-treated eyes were higher than those in the PBS-treated eyes on d 7 (P},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6610}
}