@article{APS6554,
author = {Hong-Xin Wang and Liang Tao and Man-Ren Rao},
title = {Inhibitory effects of nifedipine on DNA and protein synthesis in cultured cardiac nonmyocytes of neonatal rats},
journal = {Acta Pharmacologica Sinica},
volume = {18},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To observe the inhibitory effects of nifedipine (Nif) on cardiac nonmyocytes
growth and proliferation.
METHODS: Using nonmyocytes in culture as a model, [3H]thymidine and [3H]leucine
incorporation were measured.
RESULTS: There was a significant decrease in cell number and in total cellular
protein after 72-h exposure to Nif 1 mumol.L-1 in the presence of angiotensin II
(Ang II). A 48-h exposure to 1, 10, 100, 1000 nmol.L-1 of Ang II caused a 19%,
35%, 46%, 48% increase in protein synthesis and 27%, 46%, 56%, 57% increase in
DNA synthesis. Nif 1, 3, and 10 mumol.L-1 were able to reduce the Ang II 100
nmol.L-1-induced increase of protein synthesis and DNA synthesis.
CONCLUSION: Nif had a direct inhibitory action on the growth of nonmyocytes,
which was related to the regression of cardical hypertrophy.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6554}
}