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8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells.

   
@article{APS6526,
	author = {Shirley X L Liu and George C Y Chiou and Zhou Chen},
	title = {8-(N,N-diethylamino)-n-octyl-3,4,5-trimethoxybenzoate actions on calcium dynamics in cultured vascular smooth muscle cells.},
	journal = {Acta Pharmacologica Sinica},
	volume = {18},
	number = {1},
	year = {2016},
	keywords = {},
	abstract = {AIM: To study 8-(N,N-Diethylamino)n-octyl-3,4,5-trimethoxybenzoate (TMB), a
potent Ca(2+)-antagonist, actions on cellular calcium dynamics in vascular smooth
muscle cell (VSMC) cultures.
METHODS: A7r5 VSMC were cultured with Fura-2 measurements of intracellular Ca2+
concentration, [Ca2+]i.
RESULTS: TMB reduced [Ca2+]i from control levels and blocked [Ca2+]i increase
caused by norepinephrine (NE) and 2,5-di (t-butyl)-1,4-benzohydroquinone (BHQ).
[Ca2+]i reduction by TMB was further enhanced by ryanodine.
CONCLUSION: TMB is an effective agent for blocking the [Ca2+]i increase caused by
NE and BHQ and for enhancing the [Ca2+]i reduction caused by ryanodine.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6526}
}