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Enhancement of interleukin-2 production and its mRNA expression by dihydroartemisinin

   
@article{APS6493,
	author = {Si-xun Yang and Shu-sheng Xie and Da-long Ma and Han-lin Gao and Zhen-zhou Long},
	title = {Enhancement of interleukin-2 production and its mRNA expression by dihydroartemisinin},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {6},
	year = {2016},
	keywords = {},
	abstract = {Immunoregulatory properties of a novel antimalarial drug dihydroartemisinin (DHA) were investigated in vitro. DHA 0.5-5 mumol.L-1 enhanced the lymphocyte proliferation induced by Con A. Interleukin 2 (IL-2) production and its mRNA expression by both Con A-stimulated mouse splenocytes and a T cell line LBRM-33-1A5 were also augmented by DHA. In contrast, DHA 0.5-5 mumol.L-1 did not show any effect on the lipopolysaccharides (LPS)-induced lymphocyte proliferation and the spontaneous and mitogen-induced proliferation of transformed T cells. These results indicated that DHA might regulate lymphocyte responses through the induction of IL-2 production and that the enhanced T cell proliferation and IL-2 production might be mediated through different pathways.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6493}
}