@article{APS6491,
author = {Tao Fu and Zhen-lun Gu and Yong-hua Xu},
title = {Modulation of bradykinin-induced intracellular Ca2+ oscillations in v-Ki-ras-transformed fibroblasts},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {6},
year = {2016},
keywords = {},
abstract = {Modulation of bradykinin (BK)-induced intracellular Ca2+ oscillations was investigated with single cell Ca2+ analysis in v-Ki-ras-transformed NIH3T3 fibroblasts. The Ca2+ oscillations were inhibited by the addition of a specific antagonist for subtype 2 of BK receptors (B2 receptor), not the antagonist for B1 receptor. Decrease of the extracellular Ca2+ concentration suppressed the [Ca2+]i oscillations and application of thapsigargin dissipated the [Ca2+]i oscillations. These findings suggest that the continuous activation of B2 receptor leading to the fluctuations of both Ca2+ influx which refills the internal Ca2+ stores, and Ca2+ mobilization from the internal stores, is essential to the occurrence of the [Ca2+]i oscillations in these cells.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6491}
}