@article{APS6454,
author = {Jun-Ping Zhang and Tang-Ming Wu and Zhen-Lin Hu and Ding-Hua Qian},
title = {Inhibitory effect of quercetin on tumor necrosis factor and interleukin-1 beta pro-osteoclastic activities},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the effects of quercetin on tumor necrosis factor (TNF) and interleukin-1 beta (IL-1 beta) pro-osteoclastic activities.
METHODS: [3H] TdR uptake by osteoblasts was used to measure cell proliferation, microspectrophotometer for cellular AIP activity using p-nitrophenyl phosphate as enzyme substrate, and radioimmunoassay for prostaglandin E2.
RESULTS: Quercetin 5-40 mumol.L-1 reduced the inhibition of cell proliferation and AIP activity induced by TNF or IL-1 beta in a concentration-dependent manner. PGE2 production stimulated by either cytokines was also reduced by quercetin at 20 and 40 mumol.L-1.
CONCLUSION: quercetin exerted a marked inhibitory effect on TNF and IL-1 activities, related to their pro-osteoclastic function.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6454}
}