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Pharmacokinetic-pharmacodynamic modeling of electroencephalographic effects of midazolam in eight Chinese men

  
@article{APS6432,
	author = {Jian-feng Lu and Gang Chen and Ben-ren Xiang and Deng-kui An},
	title = {Pharmacokinetic-pharmacodynamic modeling of electroencephalographic effects of midazolam in eight Chinese men},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {The effects of midazolam (Mid) on the electroencephalogram (EEG) were related to Mid concentrations in serum in 8 Chinese healthy male volunteers for the assessment of concentration-effect relationship. The total number of waves per second within the frequency range of 12-30 Hz (TNW12-30) in the central-occipital (C1-O1) lead EEG obtained by aperiodic analysis was used as EEG effect of the drug. The PK-PD parameters were calculated by PK-PD software using the sigmoid Emax model. They were: T1(2)keo = 1.3 +/- 0.9 min-1, EC50 = 254 +/- 54 micrograms.L-1, N = 2.9 +/- 0.6. E0 and Emax were calculated from the observed values, being 3.4 +/- 1.3 and 11.4 +/- 2.2 TNW12-30, respectively. Our results showed that the concentration-EEG effect relationship of Mid could be characterized in individual Chinese man using TNW12-30 as a measure of pharmacological response.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6432}
}