TY  - JOUR
AU  - Niu Xiao-Wei
AU  - Zeng Tao
AU  - Qu An-Lian
AU  - Kang Hua-Guang
AU  - Dai Shui-Ping
AU  - Yao Wei-Xing
AU  - Jiang Ming-Xing
PY  - 2016
TI  - Effects of 7-bromoethoxybenzene-tetrahydropalmatine on voltage-dependent currents in guinea pig ventricular myocytes
JF  - Acta Pharmacologica Sinica; Vol 17, No 3 (May 1996): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - AIM: To study the anti-arrhythmic mechanism of 7-bromoethoxybenzene-tetrahydropalmatine (EBP).  METHODS: Whole-cell current and voltage clamp on isolated guinea pig ventricular cells.  RESULTS: EBP 30 mumol.L-1 prolonged APD90 from 430 +/- 47 ms to 514 +/- 61 ms (n = 5, P < 0.05) without effects on the action potential amplitude and resting potential. Delayed outward K+ current and its tail current were blocked by EBP in a concentration-dependent fashion, while EBP did not change the amplitudes of the sodium current, the L type calcium current, and the inwardly rectifying potassium current.  CONCLUSION: The mechanism of anti-arrhythmic action of EBP was to prolong the APD through inhibiting the delayed rectified potassium current.
UR  - http://www.chinaphar.com/article/view/6413