@article{APS6413,
author = {Xiao-Wei Niu and Tao Zeng and An-Lian Qu and Hua-Guang Kang and Shui-Ping Dai and Wei-Xing Yao and Ming-Xing Jiang},
title = {Effects of 7-bromoethoxybenzene-tetrahydropalmatine on voltage-dependent currents in guinea pig ventricular myocytes},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the anti-arrhythmic mechanism of 7-bromoethoxybenzene-tetrahydropalmatine (EBP).
METHODS: Whole-cell current and voltage clamp on isolated guinea pig ventricular cells.
RESULTS: EBP 30 mumol.L-1 prolonged APD90 from 430 +/- 47 ms to 514 +/- 61 ms (n = 5, P < 0.05) without effects on the action potential amplitude and resting potential. Delayed outward K+ current and its tail current were blocked by EBP in a concentration-dependent fashion, while EBP did not change the amplitudes of the sodium current, the L type calcium current, and the inwardly rectifying potassium current.
CONCLUSION: The mechanism of anti-arrhythmic action of EBP was to prolong the APD through inhibiting the delayed rectified potassium current.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6413}
}