@article{APS6395,
author = {Li-Juan Chen and Yong Xi and Da-Wei Pang and Qi-Ting Zhou and Guo-Zhang Jin},
title = {Effect of (+/-)12-chloroscoulerine on brain dopamine receptors},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {2},
year = {2016},
keywords = {},
abstract = {\"AIM:
To assess potencies of tetrahydroprotoberberines (THPB) and hydrobenzyltetrahydroisoquinolines (HBTI) on DA receptors.
METHODS:
The receptor binding assay with calf striatum to D1 and D2 receptors, and the animal behavior tests were used.
RESULTS:
(+/-) 12-Chloroscoulerine (CSL) was the most potent one among the THPB and HBTI. The affinities of CSL to D1 and D2 receptors were 13 and 51 nmol.L-1, respectively. In rats, CSL showed an antagonistic effect on the stereotypy and induced catalepsy. In the 6-OHDA lesioned rats, however, CSL exerted the agonistic effect to DA receptors.
CONCLUSION:
CSL had dual actions to DA receptors and its effects were similar to that of (-)stepholidine.
\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6395}
}