@article{APS6381,
author = {Yan Xiong and Yuan-Jian Li and Xian-Jie Yu and Gui-Zhen Liu and Nian-Sheng Li},
title = {Endogenous inhibitors of nitric oxide synthesis and lipid peroxidation in hyperlipidemic rabbits},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To examine whether the elevation of endogenous NG, NG-dimethylarginine (DMA) content is related to lipid peroxidation in the high lipid-fed rabbit.
METHODS: In high lipid diet-fed rabbits, concentrations of serum cholesterol, triglyceride, malondialdehyde (MDA), and DMA were measured, and endothelium-dependent relaxation to acetylcholine (ACh) was tested.
RESULTS: After 6-wk on a high lipid-diet, the levels of serum total cholesterol, triglyceride, MDA, and DMA were increased vs those in control group (MDA was 2.88 +/- s 0.20 vs 1.54 +/- 0.13 nmol.L-1, P < 0.01 and DMA was 1.51 +/- 0.07 vs 0.75 +/- 0.13 mumol.L-1, P < 0.01), while the endothelium-dependent vasodilation in the isolated thoracic aorta was impaired (the maximal response to ACh was 45.59 +/- 3.10 vs 76.93 +/- 5.68%). Supplementation with vitamin E decreased MDA and DMA content and improved the endothelium-dependent vasodilation.
CONCLUSIONS: An increase in serum concentration of DMA may be secondary to the elevation of lipid peroxides in the hyperlipidemic rabbit.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6381}
}