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Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation

  
@article{APS6376,
	author = {Rui Fei and Yu Fei and Sheng Zheng and Yan-guang Gao and Hong-xia Sun and Xian-lu Zeng},
	title = {Purified polysaccharide from Ginkgo biloba leaves inhibits P-selectin-mediated leucocyte adhesion and inflammation},
	journal = {Acta Pharmacologica Sinica},
	volume = {29},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {Aim:  To investigate the anti-inflammatory mechanism of the polysaccharides of Ginkgo biloba leaves (PGBL) by inhibiting leucocyte adhesion.
Methods:  The rough PGBL were isolated and purified. The anti-inflammatory effects of purified PGBL (p-PGBL) were assayed by ear edema induced by xylol and the acute peritonitis model in mice. The effect of p-PGBL on inhibiting the interaction between P-selectin and its ligands was investigated by flow cytometry and flow chamber.
Results:  p-PGBL could effectively inhibit the acute inflammation in mice and interfere with the adhesion of HL-60 cells, a human leukaemia cell line, or neutrophils to P-selectin in static conditions, as well as the adhesion of neutrophils to Chinese hamster ovary cells expressing human P-selectin and human umbilical vein endothelial cells in flow conditions in a dose-dependant manner.
Conclusions:  p-PGBL can inhibit the inflammatory process through interfering with the interaction between P-selectin and its ligands.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6376}
}