@article{APS6363,
author = {Jie Wu and Xiao-jiang Yu and Xin Ma and Xiao-guang Li and Dong Liu},
title = {Electrophysiologic effects of total flavones of Hippophae rhamnoides L on guinea pig papillary muscles and cultured rat myocardial cells},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {4},
year = {2016},
keywords = {},
abstract = {The effects of total flavones of Hippophae rhamnoides L (TFH) were evaluated using conventional microelectrode technic. After administration of TFH 100-200 mg.L-1, the action potential duration of 50% repolarization (APD50) was shortened both in cultured rat myocardial cells and in guinea pig papillary muscles. The slope of phase 4 of depolarization (SP4) in cultured rat myocardial cells was decreased and the contractile force (CF) in guinea pig papillary muscles was weakened. Arrhythmias evoked by strophantin G in guinea pig papillary muscles were suppressed by TFH 100 mg.L-1. These findings suggested that the influence of TFH on myocardial cells may be resulted mainly from its inhibition of Ca2+ influx and its interference with intracellular Ca2+ reservoir.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6363}
}