@article{APS6357,
author = {Xiao-ping Yang and Zhan-jun Wu and YAN-fang Xu and Wei Dong and Wei Yang and Shao-xuan Fu and Yun-shan Li},
title = {Effects of inhibitor of endothelium-derived relaxing factor on hypoxic contraction of isolated pig coronary artery},
journal = {Acta Pharmacologica Sinica},
volume = {15},
number = {4},
year = {2016},
keywords = {},
abstract = {Exposure of isolated pig coronary artery with endothelium intact to hypoxia Krebs-Henseleit solution aerated with 95% N2 + 5% CO2 caused a transient contractile response, and the coronary artery without endothelium exhibited a gradual decrease in basal tension. The endothelium-dependent contractile response to hypoxia was almost completely blocked by nitro-L-arginine (0.2 mmol.L-1), and inhibited by methylthioninium chloride (10 mumol.L-1). The inhibitory effect of the NLA was partially reversed by L-arginine (2 mmol.L-1). Sodium nitroprusside (10 mumol.L-1) was also completely antagonized and nicorandil (0.3 mol.L-1) remarkably reduced the hypoxic contractile response. Tetraethylammonium (10 mmol.L-1) and glibenclamide (1 mumol.L-1) had little effect on hypoxia-induced vascular contraction, whereas cromakalim (1 mumol.L-1) produced obvious relaxing effect on hypoxic response. These results suggest that suppression of basally released nitric oxide (NO) is an important mechanism of coronary vasoconstriction induced by hypoxia},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6357}
}