@article{APS6336,
author = {Jing Dong and Xue Yu and Lei Wang and Ye-bin Sun and Xi-jing Chen and Guang-ji Wang},
title = {Effects of cyclosporin A and itraconazole on the pharmacokinetics of atorvastatin in rats},
journal = {Acta Pharmacologica Sinica},
volume = {29},
number = {10},
year = {2016},
keywords = {},
abstract = {Aim: To evaluate the effects of cyclosporin A and itraconazole, which were used as inhibitors of P-glycoprotein (P-gp) and/or cytochrome P450 (CYP) 3A4 on the pharmacokinetics of atorvastatin in rats.
Methods: The pharmacokinetic parameters of atorvastatin were measured after intravenous (2 mg/kg) and intra-gastric (10 mg/kg) administration of atorvastatin in rats, which were pretreated with cyclosporin A (5, 10, and 20 mg/kg) or itraconazole (5, 10, and 20 mg/kg).
Results: Compared with the control rats, cyclosporin A and itraconazole altered the pharmacokinetics of atorvastatin significantly. The AUC0-t values of atorvastatin after intragastric administration, pretreated with cyclosporin A (5–20 mg/kg), increased by 32.3%, 61.8%, and 187.2%, respectively, but the CLbile values decreased (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6336}
}