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4-Aminopyridine-induced licking response and histamine liberation in mice

   
@article{APS6311,
	author = {Yu-hong Lin and Jian-hua Xu},
	title = {4-Aminopyridine-induced licking response and histamine liberation in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {4-Aminopyridine (4-AP) 1 mg.kg-1 sc at the scruff induced a licking response in mice. H1 receptor blockaders, such as diphenhydramine HCl (1, 10 mg.kg-1, sc at the scruff or 40 mg.kg-1, i.p.), chlorphenamine maleate (20 mg.kg-1, i.p.), and astemizole (2 mg.kg-1, i.g.), inhibited the licking response caused by 4-AP. Repeated injections of 4-AP (1 mg.kg-1) reduced the times of lick and the histamine content in the skin of injected site. 4-AP also promoted histamine release from incubated mouse peritoneal mast cells (PMC) in a dose-dependent manner. The results indicate that the licking response may originate from the histamine liberation of mast cells.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6311}
}