@article{APS6300,
author = {Hong-fang Jin and Shu-xu Du and Xia Zhao and Hong-ling Wei and Yan-fei Wang and Yin-fang Liang and Chao-shu Tang and Jun-bao Du},
title = {Effects of endogenous sulfur dioxide on monocrotaline-induced pulmonary hypertension in rats},
journal = {Acta Pharmacologica Sinica},
volume = {29},
number = {10},
year = {2016},
keywords = {},
abstract = {Aim: The present study aimed to explore the protective effect of endogenous sulfur dioxide (SO2) in the development of monocrotaline (MCT)-induced pulmonary hypertension (PH) in rats.
Methods: Forty Wistar rats were randomly divided into the MCT group receiving MCT treatment, the MCT+L-aspartate-β-hydroxamate (HDX) group receiving MCT plus HDX treatment, the MCT+SO2 group receiving MCT plus SO2 donor treatment, and the control group. Mean pulmonary artery pressure (mPAP) and structural changes in pulmonary arteries were evaluated. SO2 content, aspartate aminotransferase activity, and gene expression were measured. Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), catalase (CAT), reduced glutathione (GSH), oxidized glutathione, and malondialdehyde (MDA) levels were assayed.
Results: In the MCT-treated rats, mPAP and right ventricle/(left ventricle+septum) increased significantly (P},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6300}
}