@article{APS6277,
author = {Ke-Hong Ding and Nian-Ci Liang},
title = {Effects of spermine on phosphorylation of phosphoinositide and 47 K protein in platelet membranes of pig},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {5},
year = {2016},
keywords = {},
abstract = {In the presence of Mg2+ and exogenous phosphatidylinositol-4-phosphate, swine thrombocytic membranes were incubated with [gamma-32P]ATP at 30 degrees C for 3 min and the incorporations of 32P into phospholipids and proteins were measured. Spermine stimulated the formation of phosphatidylinositol-4,5-bisphosphate (optimal concentration 0.25 mmol.L-1) and inhibited the phosphorylation of 47 K protein (IC50 1 mmol.L-1). This helps to clarify the effect of spermine on cell growth and proliferation.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6277}
}