@article{APS6276,
author = {Chao-Yu Miao and Quan-Ying Zhu and You-Cai Yang and Ding-Feng Su},
title = {Antihypertensive effects of atenolol and nitrendipine alone or in combination on three hypertensive models of rats},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {5},
year = {2016},
keywords = {},
abstract = {The antihypertensive effects of atenolol (Ate) or nitrendipine (Nit) alone or in combination (Ate+Nit) were studied in conscious experimental hypertensive rats. The hypotensive effects of single ig of Ate 20 + Nit 10 mg.kg-1 were rapid and persistent in spontaneously hypertensive rats (SHR). In renovascular hypertensive rats (RVHR) and DOCA-salt hypertensive rats (DHR), Ate+Nit (6 + 3, 20 + 10, 60 + 30 mg.kg-1) given ig once a day for 10 d reduced the blood pressure in a dose-dependent manner. But Ate 20 mg.kg-1 or Nit 10 mg.kg-1 alone given ig once a day for 10 d caused no obvious reduction in blood pressure in RVHR, DHR, and SHR q = 1.32. These results revealed that the synergy is present in the antihypertensive action of Ate+Nit.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6276}
}