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Calcium antagonism of anisodamine on isolated rabbit thoracic aorta

   
@article{APS6275,
	author = {Jin-Ming Chen and Ming-Zhi Zhang and Shu-Ling Gu and Guang-Yi Zhang},
	title = {Calcium antagonism of anisodamine on isolated rabbit thoracic aorta},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Anisodamine (Ani) or verapamil (Ver) relaxed the contracted thoracic aortic strips induced by CaCl2 and KCl in a noncompetitive manner with pD2' 3.6 and 5.8, respectively. Ani 50 mumol.L-1 and Ver 1 mumol.L-1 inhibited the intracellular Ca(2+)-dependent component of norepinephrine-induced contraction of aorta, but Ani 0.1 mmol.L-1 did not decrease the extracellular Ca(2+)-dependent component. In the presence of Ca2+, Ani 2.3 mumol.L-1 inhibited the proliferation of aortic smooth muscle cells. In the absence of Ca2+, the effect induced by Ani was biphasic-stimulatory at 2.3 mumol.L-1 concentrations and inhibitory at 61.7 mumol.L-1 concentrations. These results suggest that Ani, similar to Ver, mainly inhibits the potentially operated calcium channels.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6275}
}