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Feed-back regulation of presynaptic D2 receptors blockaded by l-stepholidine and l-tetrahydropalmatine

   
@article{APS6274,
	author = {Li-Juan Chen and Xin Guo and Qing-Mei Wang and Guo-Zhang Jin},
	title = {Feed-back regulation of presynaptic D2 receptors blockaded by l-stepholidine and l-tetrahydropalmatine},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {The activity of tyrosine hydroxylase by accumulation of L-dopa content in the striatum under decarboxylase inhibitor (benserazide, 400 mg.kg-1) was measured by HPLC-ECD to ascertain whether l-SPD possesses an agonistic or antagonistic effect on D2 receptor subtype. The accumulated L-dopa content was increased with 1,4-butyrolactone (BL, 750 mg.kg-1) to 1.8 +/- s 0.6 micrograms.g-1 in rat striatum. After the rats were ip l-SPD 5 mg.kg-1 or l-tetrahydropalmatine (l-THP) 10-20 mg.kg-1, the increment of L-dopa level was much more than that in the BL group (P < 0.01) in a dose related manner. On the contrary, apomorphine (ip 5 mg.kg-1) abolished the accumulation of L-dopa induced by BL. Furthermore, l-SPD and l-THP not only reversed the negative feed-back regulation by apomorphine on the accumulated level of L-dopa, but also increased this level over the accumulation by BL. These results showed that l-SPD and l-THP do possess the antagonistic effect on presynaptic DA receptor (D2) without agonistic effect.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6274}
}