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Effect of cimetidine and ranitidine on absorption of [125I]levothyroxine administered orally

   
@article{APS6258,
	author = {Gerard Jonderko and Krzysztof Jonderko and Czeslaw Marcisz and Anna Kotulska},
	title = {Effect of cimetidine and ranitidine on absorption of [125I]levothyroxine administered orally},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {5},
	year = {2016},
	keywords = {},
	abstract = {Female patients with a simple goiter were pretreated on 2 occasions (at an interval of 4 wk) with po placebo or 400 mg cimetidine (Cim) (Group A, n = 10), or with placebo or 30 mg ranitidine (Ran) (Group B, n = 10), 90 and 150 min, respectively, prior to the po gelatin capsules containing [125I]levothyroxine ([125I]LT4). A double-blind randomized study protocol was kept. Venous blood samples were taken at 15, 30, 45, 60, 75, 90, 105, 120, 150, 180, 210, and 240 min after po [125I]LT4 and the radioactivities in serum were counted. Similar [125I]LT4 radioactivities were found after placebo pretreatment in both groups: AUC 467 +/- 82 in Group A vs 459 +/- 109 in Group B. Cimetidine decreased the serum [125I]LT4 radioactivities: AUC371 +/- 72 (Cim) vs 467 +/- 82 (placebo) (P < 0.01), but Ran did not: AUC 477 +/- 132 (Ran) vs 459 +/- 109 (placebo) (P > 0.05).},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6258}
}