@article{APS6254,
author = {Wen-Duo Du and Shi-Bo Xu},
title = {Suberogorgin vs N-cyclohexyl suberogorgamide effects on urine, respiration, and blood pressure in rat and cat.},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {1},
year = {2016},
keywords = {},
abstract = {\"AIM:
To compare the pharmacological actions of suberogorgin (Sub) and N-cyclohexyl suberogorgamide (N-CS).
METHODS:
Urine was collected from rats and anesthetized cats which had been loaded with water. The concentrations of Na+ and K+ in urine were determined in ICAP-9000 atomic emission spectrometry. An equitoxic (1/50 LD50) dose of Sub and N-CS was used in cats.
RESULTS:
The cat urine was decreased by 63% after i.v. Sub 0.4 mg.kg-1, but increased by 25% after i.v. N-CS 1.5 mg.kg-1, lasting at least 9 h. Sub and N-CS increased the respiratory rate and tidal volume, but did not change the blood pressure. The rat urine was decreased by 48% after i.p. Sub 1.3 mg.kg-1, but increased by 14% after i.p. N-CS 3.2 mg.kg-1. Sub and N-CS increased the concentrations of Na+ and K+ in rat urine. These effects lasted at least 24 h.
CONCLUSION:
Sub is an antidiuretic, while N-CS is a diuretic drug.
\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6254}
}