@article{APS6252,
author = {Yi-Jia Lou and Guang-Sheng Ding and Zeng-Hong Tu},
title = {Toxicity to transferred rat embryos after aspirin treatment during preimplantation stage in vivo.},
journal = {Acta Pharmacologica Sinica},
volume = {17},
number = {1},
year = {2016},
keywords = {},
abstract = {\"AIM:
To explore the relationship between drug-induced blastopathies and post-implantation embryotoxicity or developmental defects.
METHODS:
Pregnant rats on d 3 were given intragastrically aspirin (0.25, 0.5, and 1 g.kg-1). On d 4, the blastocysts were transferred into the uterine horns of pseudopregnant rats (made by mating with male rats which had been given intragastrically 3-chloro-1,2-propanediol 5 mg.kg-1 for 5 d). Uterine contents were examined at term.
RESULTS:
The frequency of blastocysts with morphological alterations (FBMA) was increased on d 4 of gestation. The implantation rate was lower than that of the controls. A dose-related increase in resorption (55.2%, 69.5%, and 85.2%) and malformation rate (3.8%, 44.4%, and 25%), and decrease in viability rate of fetuses (44.8%, 30.5%, and 14.8%) were observed in test groups with correlations to FBMA.
CONCLUSION:
Embryotoxicity and fetal malformations were induced by treatment of aspirin before implantation in a dose-dependent manner.
\"},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6252}
}