TY  - JOUR
AU  - Zhu Zi-Tao
PY  - 2016
TI  - Effect of desipramine on spontaneous activity of hippocampal CA1 neuron after transient cerebral ischemia in rats.
JF  - Acta Pharmacologica Sinica; Vol 17, No 1 (January 1996): Acta Pharmacologica Sinica
Y2  - 2016
KW  - 
N2  - "AIM:     To study the spontaneous firing of CA1 neurons in rat hippocampus after transient cerebral ischemia and the effect of desipramine (Des) on the post-ischemic electric activity of CA1 neurons.    METHODS:     Single-unit extracellular recordings were performed in rats on d 3 after 10 min of cerebral ischemia by occlusion of 4 arteries. Des and saline were injected into a tail vein. The histological changes of CA1 neurons was assessed by the neuronal density of the CA1 sector.    RESULTS:     The spontaneous firing rate of CA1 neurons on d 3 after ischemia was enhanced in comparison with the control value. Des (0.2 and 0.4 mg.kg-1, i.v., n = 5 & 6, respectively) reduced dose-dependently the increase of firing rate with maximal inhibition by 6 min (58% & 85%) to 9 min (69% & 94%) (vs vehicle group, P < 0.01). About 50% cells in CA1 region showed necrotic changes.    CONCLUSION:     Des antagonized the hyperexcitability of CA1 neurons after cerebral ischemia.  "
UR  - http://www.chinaphar.com/article/view/6247