@article{APS6233,
author = {Jin-Xia Zhu and Shu-Ben Tang and Xiao-Yin Wu and Bo Jiang},
title = {Role of catecholamines in action of nicotine on slow action potentials in guinea pig papillary muscles},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {4},
year = {2016},
keywords = {},
abstract = {The action potential duration (APD) of histamine-induced slow action potentials (SAP) and force of contraction (FC) were potentiated by nicotine (0.6-1.0 mmol.L-1) on guinea pig papillary muscles in a concentration-dependent manner. In the presence of atropine, nicotine concentration dependently suppressed the action potential amplitude (APA), APD, the maximal upstroke velocity (Vmax), and FC in catecholamine-depleted (reserpine 2.5 mg.kg-1 ip, 15 h prior to the experiment) muscles. Nicotine (0.6 mmol.L-1) itself induced SAP and enhanced FC. These 2 effects were antagonized by verapamil. A linear relationship existed between APA of nicotine-induced SAP and 1g [Ca2+]0 with a slope of 23.2 mV for a 10-fold change in [Ca2+]0. These results suggested that the effects of nicotine on enhancing Isi were mediated by the release of catecholamines in myocardium.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6233}
}