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Effect of mexiletine on energy metabolism of ischemic brain in mice

   
@article{APS6230,
	author = {Li-Ping Dong and Tian-You Wang and Li Zhang},
	title = {Effect of mexiletine on energy metabolism of ischemic brain in mice},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {After 30 s ischemia induced by decapitation, the contents of ATP and phosphocreatine (PC) in mouse brain reduced, while that of lactic acid (LA) increased. When mexiletine (3.1-50 mg.kg-1) was injected ip 30 min before decapitation, the brain ATP and PC reduction, and LA accumulation were both alleviated in a dose-dependent manner. These findings suggested that mexiletine was effective in ameliorating the energy exhaustion in the ischemic brain.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6230}
}