@article{APS6225,
author = {Pei Rong and De-Zai Dai and Jiao-E Zhang},
title = {Global depletion of myocardial norepinephrine and ATP after left coronary artery occlusion in rats},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {4},
year = {2016},
keywords = {},
abstract = {After ligation of the left coronary artery in rats, myocardial norepinephrine (NE) and ATP depletions in both infarcted (IZ) and non-infarcted zone (NIZ) were studied. In IZ, the depletions of NE and ATP were biphasic and the depleting rate constants were found to be K1 = 0.71 h-1 and K2 = 0.015 h-1 for NE, and K1' = 0.52 h-1 and K2' = 0.016 h-1 for ATP. In NIZ, the depletion of NE was monophasic, slowly progressive, and quite durable with rate constant K3 = 0.018 h-1. The depletion of ATP was transient. Propranolol (Pro) and verapamil (Ver) were beneficial but only partly effective against NE and ATP depletions.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6225}
}