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Global depletion of myocardial norepinephrine and ATP after left coronary artery occlusion in rats

  
@article{APS6225,
	author = {Pei Rong and De-Zai Dai and Jiao-E Zhang},
	title = {Global depletion of myocardial norepinephrine and ATP after left coronary artery occlusion in rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {4},
	year = {2016},
	keywords = {},
	abstract = {After ligation of the left coronary artery in rats, myocardial norepinephrine (NE) and ATP depletions in both infarcted (IZ) and non-infarcted zone (NIZ) were studied. In IZ, the depletions of NE and ATP were biphasic and the depleting rate constants were found to be K1 = 0.71 h-1 and K2 = 0.015 h-1 for NE, and K1' = 0.52 h-1 and K2' = 0.016 h-1 for ATP. In NIZ, the depletion of NE was monophasic, slowly progressive, and quite durable with rate constant K3 = 0.018 h-1. The depletion of ATP was transient. Propranolol (Pro) and verapamil (Ver) were beneficial but only partly effective against NE and ATP depletions.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6225}
}