@article{APS6216,
author = {Jin-Ping Wang and Lu Liu and Xiao Liu and Xiang-Yuan Yang and Duan Li and Guo-Qing Ge and Qi-Wen Huang},
title = {Serum concentration fluctuation and bioavailability comparison between indomethacin sustained-release and conventional capsules during steady state},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {4},
year = {2016},
keywords = {},
abstract = {The comparison between indomethacin conventional capsule (CC) po 25 mg q 8 h or 25 mg tid and indomethacin sustained-release capsule (SRC) po 25 mg bid in human by crossover design showed that both maximal serum concentration (Cmax) and fluctuation index (FI%) of SRC were significantly lower than those of CC during steady state (P < 0.01). No practical differences were observed between the 2 preparations in the trough serum concentration (Cmin) and area under serum concentration-time profiles (AUC0-tau) (P > 0.05). The time period reaching maximal serum concentration (Tmax) of SRC was much more delayed than that of CC (P < 0.01). It suggested that SRC possesses a better controlled release property and could avoid a higher serum peak concentration of CC.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6216}
}