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Inhibition of mexiletine on sodium current in dorsal root ganglion neurons of rats

   
@article{APS6206,
	author = {Xu-feng Zhang and Tian-you Wang and Li Zhang},
	title = {Inhibition of mexiletine on sodium current in dorsal root ganglion neurons of rats},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Using whole-cell configuration of patch clamp technique we found that mexiletine (Mex) reversibly inhibited the sodium current in a voltage- and use-dependent manner in cultured dorsal root ganglion (DRG) neurons. The threshold concentration of Mex was 5 mumol.L-1. The inhibitory action heightened with increasing concentrations of Mex. Complete inhibition was achieved at 150 mumol.L-1 and the 50% inhibition concentration was 31 mumol.L-1. It is suggested that the inhibition of Mex on sodium current in neurons may be one of the mechanisms of its anti-ischemic and anti-anoxic effects on the neuron.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6206}
}