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Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes

   
@article{APS6199,
	author = {Wen-jie Zhang and Guo-gan Zhong and Yan Jiang and Xiao-ming Wang and Zhong-feng Wang},
	title = {Single channel analysis on calcium channel blockade action of panaxadiol and panaxatriol saponins on cultured rat ventricular myocytes},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {Wistar rat ventricular myocytes were isolated. Panaxadiol saponins 1500 micrograms.ml-1, panaxatriol saponins 300 micrograms.ml-1, verapamil 37.5 micrograms.ml-1, or BAY k 8644 5 mumol.L-1 were added into the bath solution separately. The single channel activities of L, T, and B type calcium channels were recorded before and after the administration, using voltage patch-clamp technique in cell-attached configuration. The calcium channel blockade effect of these 2 groups of ginsenosides was authenticated verified. The mechanism existed in the decrease in both the open time and the open-state probability of the calcium channel},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6199}
}