@article{APS6169,
author = {Xi-Lu Jin and Xiu-Yuan Zhu},
title = {Pharmacokinetics of puerarin in rats, rabbits, and dogs},
journal = {Acta Pharmacologica Sinica},
volume = {13},
number = {3},
year = {2016},
keywords = {},
abstract = {The puerarin was determined by HPLC with fluorescence detection. The plasma concentration-time course of puerarin in rats and dogs after iv was best fitted to a two-compartment open model, while that in rabbits was best fitted to a three-compartment open model. Species specificity was found among rats, rabbits, and dogs, calculated with compartment model program. The T1/2 beta after iv puerarin 9 mg.kg-1 in rats, rabbits, and dogs were 11, 21, and 67 min, respectively. There were no significant differences in pharmacokinetic parameters after iv 4.5-30 mg.kg-1 to rabbits and dogs.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6169}
}