@article{APS6167,
author = {Zheng-ping JIA and Jing-wen XIE and Ting-quan XIE},
title = {Pharmacokinetics of 4-[4\"-(2\",2\",6\",6\"-tetramethyl-1\"-piperidinyloxy) amino]-4'-demethylepipodophyllotoxin in mice bearing sarcoma 180},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {3},
year = {2016},
keywords = {},
abstract = {AIM: To study the pharmacokinetics of 4-[4\"-(2\",2\",6\",6\"-tetramethyl- 1\"-piperindyloxy) amino]-4'-demethylepipodophyllotoxin (GP-7) in mice bearing sarcoma 180.
METHOD: Using HPLC with a uv detector at 285 nm.
RESULTS: The plasma concentration-time course of GP-7 in mice was best fitted to a 2-compartment open modle after iv 20, 60 mg.kg-1. At both doses the plasma T1/2 beta was around 40 min. The highest concentration was found in liver and lung. The level of GP-7 was higher in tumor than in kidney, spleen, and bone marrow after ip 20 mg.kg-1 for 10 d. Urinary excretion of GP-7 as unchanged drug accounted for about 20% of the administered doses 72 h after injection.
CONCLUSION: GP-7 disappeared more slowly from the plasma of mice bearing sarcoma 180, distributed extensively over the tissues and was partially excreted from urine. The concentrition of GP-7 in tumor was higher.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6167}
}