@article{APS6143,
author = {Yan JIANG and Wei LIU and Guo-gan ZHONG and Shi-jie YANG and Wen-jie ZHANG and Jun-jie WEI and Hong-jun ZHANG and Lin WANG},
title = {Influence of the 2nd and 3rd grade abstracts from scorpion venom of Buthus martensii Karsch on action potentials of fast response myocardiocytes},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To screen the active components of sodium channel blockade action from Buthus martensii Karsch (BMK) scorpion venom.
METHODS: Myocardiocytes of mice were cultured. Action potentials of fast response myocardiocytes were recorded. The effects of 22 contents of BMK scorpion venom in a concentration of 3 mg.L-1 were tested and compared with that of TTX 2.5 mg.L-1, nimodipine (Nim) 3 mg.L-1 and BaCl2 24.4 mg.L-1.
RESULTS: BMK-1 and other 19 contents significantly decreased depolarization parameters Vmax, APA, OS, and MDP, which was similar to that of TTX and different from that of Nim and BaCl2.
CONCLUSION: The variations in the action potentials of fast response myocardiolcytes indicated that 20 contents of BMK scorpion venom had sodium channel blockade action.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6143}
}