How to cite item

Protective effect of cycloprotobuxine-A against cardiac arrhythmias induced by ouabain

   
@article{APS6141,
	author = {Yong-Xiao Wang and Yue-Hua Tan and Bao-Heng Sheng},
	title = {Protective effect of cycloprotobuxine-A against cardiac arrhythmias induced by ouabain},
	journal = {Acta Pharmacologica Sinica},
	volume = {13},
	number = {3},
	year = {2016},
	keywords = {},
	abstract = {Cycloprotobuxine-A (CPB-A) 1-4 mg.kg-1 iv increased the dose of ouabain required to induce ventricular arrhythmias in guinea pigs. At the equitoxic doses (1/50 LD50), CPB-A was more potent than cyclovirobuxine-D and amiodarone. Pretreatment with reserpine (5 mg.kg-1 ip), vagotomy or pithing spinal cord did not prevent the action of CPB-A, which indicate that the protective effect of CPB-A may be due to its direct action on myocardium without the involvement of nervous system. In isolated guinea pig ventricular muscles, CPB-A 3 mumol.L-1 consistently decreased the amplitude of oscillatory afterpotentials (OAP) and blocked triggered activity elicited by ouabain. At 30 mumol.L-1, CPB-A abolished the appearance of OAP. It seems that one of the mechanisms for the anti-arrhythmic action of CPB-A was a decrease in the amplitude of OAP.},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6141}
}