@article{APS6131,
author = {Xiu-juan YAO and Yue-hua TAN and Zi-chao XU and Xiao-ye LI and Shui-ying CHEN},
title = {Effects of anisodamine against myocardial ischemia-reperfused injuries and antilipid peroxidation},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: Anisodamine (Ani), an alkaloid first isolated in China. To study the relationship between the protective effects of Ani on myocardial cells of reperfused injuries and the antilipid peroxidation.
METHODS: Coronary ligation for 15-min followed by 10 min reperfusion was performed in anesthetized rats.
RESULTS: Ani 1, 3, 5 mg.kg-1 i.v. 1 min prior to reperfusion could dose-dependently lower the release of creatine kinase (282 +/- 29, 252 +/- 53, 226 +/- 50), counteract the increase of malondialdehyde content (3.3 +/- 1.3, 3.2 +/- 1.6, 3.1 +/- 1.2) in the reperfused myocardium and preserve the SOD activity (41 +/- 7, 46 +/- 8, 55 +/- 8). Ani completely abolished the drop in the contents of principal unsaturated fatty acids (oleic, linoleic, and arachidonic acids) of the membrane lipids in the reperfused myocardium. SOD 75 U.kg-1 i.v. 1 min prior to reperfusion exerted similar effects like Ani 3 mg.kg-1.
CONCLUSION: It is suggested that the antilipid peroxidative effect of Ani may contribute to its protection against reperfusion-induced myocardial injuries.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6131}
}