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Blocking effect of rhynchophylline on calcium channels in isolated rat ventricular myocytes

   
@article{APS6110,
	author = {Xiao-liang Wang and Li-ming Zhang and Zheng Hua},
	title = {Blocking effect of rhynchophylline on calcium channels in isolated rat ventricular myocytes},
	journal = {Acta Pharmacologica Sinica},
	volume = {15},
	number = {2},
	year = {2016},
	keywords = {},
	abstract = {The effect of rhynchophylline (Rhy) on L-type Ca2+ channel current was studied in rat ventricular myocytes using patch-clamp whole-cell recording technique. When the holding potential was -40 mV, cells were depolarized to 0 mV for 250 ms at frequency of 0.5 Hz, Rhy 10 and 50 mumol.L-1 reduced verapamil-sensitive Ca2+ inward current by 60% and 80%, respectively, without affecting the voltage-dependency of the maximal activation of Ca2+ current. This indicated that the effect of Rhy on the activation of Ca2+ channel was voltage-independent. The effect of Rhy on Ca2+ current reached the maximum at 10 min and was partially recovered by washout of Rhy. A pD2 value of 5.91 and Hill coefficient of 1.1 were obtained from the concentration-response curve},
	issn = {1745-7254},	url = {http://www.chinaphar.com/article/view/6110}
}