@article{APS6101,
author = {Jie LIU and Yaping LIU and Curtis D KLAASSEN},
title = {Protective effect of oleanolic acid against chemical-induced acute necrotic liver injury in mice},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {2},
year = {2016},
keywords = {},
abstract = {AIM: To evaluate the protective effect of oleanolic acid (OA) against necrotic liver injury.
METHODS: Mice were pretreated with OA (200 mumol.kg-1, sc for 3 d), and subsequently administered hepatotoxicants. Liver damage was assessed by quantifying serum activities of alanine aminotransferase and iditol (sorbitol) dehydrogenase, as well as by histopathological examination.
RESULTS: OA pretreatment dramatically diminished CCl4-, bromobenzene-, acetaminophen-, phalloidin-, and cadmium-induced liver injury, and decreased the hepatotoxicity of D-galactosamine plus endotoxin, thioacetamide, furosemide, and colchicine. However, OA had no effect on the toxicity of dimethylnitrosamine, alpha-amanitin, chloroform, and allyl alcohol.
CONCLUSION: OA protects against many, but not all, hepatotoxicants, and the hepatoprotective effect of OA may involve multiple mechanisms.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6101}
}