@article{APS6099,
author = {Yong DING and Da-kuang HUANG and Jian-ping LUO},
title = {A simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics},
journal = {Acta Pharmacologica Sinica},
volume = {16},
number = {1},
year = {2016},
keywords = {},
abstract = {AIM: To establish a simple method for estimating half-life of drugs obeying Michaelis-Menten elimination kinetics.
METHODS: A linear relationship is sketched between elimination half-life and drug concentration in blood that obey Michaelis-Menten elimination kinetics. A simple method is proposed to draw a regression line of blood drug concentration vs time after a single bolus intravenous injection.
RESULTS & CONCLUSION: The elimination half-life can be read from the regression line. The method can also be used to estimate the time required for the plasma concentration of a drug to decrease any fraction.},
issn = {1745-7254}, url = {http://www.chinaphar.com/article/view/6099}
}